雄激素受体基因CAG、GGN重复片段多态性与身体质量指数/腰臀比的关联性

doi:10.16098/j.issn.0529-1356.2016.04.017

解剖学报 ›› 2016, Vol. 47 ›› Issue (4): 534-538.doi: 10.16098/j.issn.0529-1356.2016.04.017

雄激素受体基因CAG、GGN重复片段多态性与身体质量指数/腰臀比的关联性

张钏¹ 陆宏²裴利国³ 郝胜菊¹闫有圣¹ 郑雷¹党洁² 霍正浩^2*

1. 甘肃省医学遗传学中心, 甘肃省妇幼保健院, 兰州 730050; 2. 生育力保持教育部重点实验室, 宁夏生殖与遗传重点实验室, 宁夏医科大学基础医学院, 银川 750004; 3. 宁夏医科大学总医院生殖中心, 银川, 宁夏 750004

收稿日期:2015-11-13 修回日期:2016-04-05 出版日期:2016-08-06 发布日期:2016-08-06
通讯作者: 霍正浩 E-mail:zhangchuan0404@163.com
基金资助:
性类固醇激素及代谢通路基因多态性与人类指长比的关联性研究;指长比及其波动性不对称与胚胎起源成人疾病的相关性研究

Relationship of body mass index/waist-hip ratio with androgen receptor CAG and GGN repeat polymorphism

ZHANG Chuan¹ LU Hong²PEI Li-guo³HAO Sheng-ju¹YAN You-sheng¹ ZHENG Lei¹ DANG Jie² HUO Zheng-hao ^2*

1.Gansu Province Medical Genetics Center, Gansu Provincial Maternity and ChildCare Hospital, Lanzhou 730050, China;2.Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Department of Medical Genetics and Cell Biology, Ningxia Medical University, Yinchuan 750004, China; 3.Reproductive Medicine Center，General Hospital of Ningxia Medical University, Yinchuan 750004, China

Received:2015-11-13 Revised:2016-04-05 Online:2016-08-06 Published:2016-08-06
Contact: HUO Zheng-hao E-mail:zhangchuan0404@163.com

摘要/Abstract

摘要：

目的探讨雄激素受体基因CAG、GGN重复片段多态性与身体质量指数(BMI)、腰臀比(WHR)之间的关联性。方法研究对象来自宁夏医科大学2011级健康学生共 654 例, 男性280例，女性374例，平均年龄（20.35±1.24）岁。用ABI 3730XL测序仪测定AR基因的(CAG)n及(GGN)n重复数目，直接测量法测得身高、体重、腰围与臀围。结果 BMI与WHR的分布存在性别差异。较长GGN等位基因与女性BMI呈正相关(P<0.05)，AR基因的(CAG)n与女性BMI无相关性(P>0.05)；男性AR基因的(CAG)n及(GGN)n与BMI及WHR无相关性(P>0.05)。结论 BMI与WHR在不同性别间的分布存在差异性；较长GGN等位基因与女性BMI存在关联性。

关键词: 身体质量指数, 腰臀比, CAG 重复多态性, GGN 重复多态性, 直接测量法, 人

Abstract:

Objective Body mass index (BMI) and waisthip ratio (WHR) are sexually dimorphic. The main reason for the stability of sexual dimorphism of BMI and WHR is the sex-hormone profile of an individual. Variability in testosterone levels has been related to BMI and WHR. At the molecular level, the effect of androgens is mediated through the activation of androgen receptor (AR). The CAG/GGN repeat polymorphisms of the AR gene are associated with AR activity. Thus, we aimed to investigate the effect of CAG/GGN repeat polymorphisms in AR on BMI and WHR in Chinese. Methods BMI was calculated as weight/height squared (kg/m²). WHR was calculated as waist/hip. AR CAG/GGN repeat polymorphisms were genotyped by ABI 3730 DNA analyzer. Results BMI and WHR were different between males and females. The longer GGN allele was positively associated with BMI of females (P<0.03). There was no association between WHR and AR CAG or GGN polymorphisms (all, P>0.05).We did not find any relationship between AR CAG polymorphism and BMI(all,P>0.05). Conclusion The relationship between AR CAG/GGN repeat polymorphisms and BMI/WHR are likely to be more complex than previously appreciated.

Key words: Body mass index, Waist-hip ratio, CAG repeat polymorphism, GGN repeat polymorphism, Direct measurement, Human

张钏陆宏裴利国郝胜菊闫有圣郑雷党洁霍正浩. 雄激素受体基因CAG、GGN重复片段多态性与身体质量指数/腰臀比的关联性[J]. 解剖学报, 2016, 47(4): 534-538.

ZHANG Chuan LU Hong PEI Li-guo HAO Sheng-ju YAN You-sheng ZHENG Lei DANG Jie HUO Zheng-hao. Relationship of body mass index/waist-hip ratio with androgen receptor CAG and GGN repeat polymorphism[J]. Acta Anatomica Sinica, 2016, 47(4): 534-538.

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雄激素受体基因CAG、GGN重复片段多态性与身体质量指数/腰臀比的关联性

Relationship of body mass index/waist-hip ratio with androgen receptor CAG and GGN repeat polymorphism

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