细胞自噬在宫颈癌中的相关研究进展

doi:10.16098/j.issn.0529-1356.2017.01.020

解剖学报 ›› 2017, Vol. 48 ›› Issue (1): 111-114.doi: 10.16098/j.issn.0529-1356.2017.01.020

细胞自噬在宫颈癌中的相关研究进展

童焰¹ 谭布珍^1* 方玉婷¹ 赖智清² 王玉¹ 王小红³

1. 南昌大学第二附属医院妇产科，南昌 330006; 2. 南昌大学第二附属医院超声科, 南昌 330006; 3. 江西省上饶市广丰区人民医院妇产科，江西上饶 334600

收稿日期:2016-01-13 修回日期:2016-08-25 出版日期:2017-02-06 发布日期:2017-02-06
通讯作者: 谭布珍 E-mail:tanbuzhen@tom.com

Related research progress of autophagy in cervical cancer cells

TONG Yan¹TAN Bu-zhen ^1* FANG Yu-ting¹ LAI Zhi-qing² WANG Yu¹WANG Xiao-hong³

1. Department of Obstetrics and Gynecology, Second Affiliated Hospital of Nanchang University, Nanchang 330006,China; 2. Department of Ultrasound, Second Affiliated Hospital of Nanchang University, Nanchang 330006,China; 3. Department of Obstetrics and Gynecology, Guangfeng District People’s Hospital, Jiangxi Shangrao 334600, China

Received:2016-01-13 Revised:2016-08-25 Online:2017-02-06 Published:2017-02-06
Contact: TAN Bu-zhen E-mail:tanbuzhen@tom.com

摘要/Abstract

摘要：

细胞自噬指细胞利用溶酶体降解细胞质中错误折叠的蛋白质及受损细胞器等，重新利用降解物质及胞内有害物质的过程，以维持细胞内环境稳定。正常状态下细胞的自噬维持在低水平，当细胞处在不利因素条件下，自噬也会被激活应对不利因素。自噬在肿瘤发生、发展、转移、复发、药物抵抗等方面有着重要作用，但自噬在这些方面的详细机制仍不清楚。我们在文中对宫颈癌细胞中自噬相关基因的表达情况进行了阐述，自噬治疗在宫颈癌中具有重要的应用前景。

关键词: 宫颈癌, 细胞自噬, Beclin-1, 人类乳头瘤病毒, Klotho, 微管相关蛋白1轻链3

Abstract:

Cell autophagy refers to use lysosomes to degrade the misfolded proteins and the damaged organelles in the cytoplasm. This process can reuse the intracellular degradation substances in order to maintain stable environment in the cell.Normal cells maintain at a low level of autophagy. When a cell is under the condition of unfavorable factors， its autophagy can be activated against unfavorable factors.Autophagy plays an important role in cancer occurrence,development, metastasis, recurrence and drug resistance, but the detailed mechanism of autophagy in these areas is still unclear.In this paper, the autophagy\| related genes in cervical cancer cells and their application in cervical cancer treatment are reviewed.

Key words: Cervical cancer, Cell autophagy, Beclin 1, Human papilloma virus, Klotho;Microtuble associated protein light chain 3

童焰谭布珍方玉婷赖智清王玉王小红. 细胞自噬在宫颈癌中的相关研究进展[J]. 解剖学报, 2017, 48(1): 111-114.

TONG Yan TAN Bu-zhen FANG Yu-ting LAI Zhi-qing WANG Yu WANG Xiao-hong. Related research progress of autophagy in cervical cancer cells[J]. Acta Anatomica Sinica, 2017, 48(1): 111-114.

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细胞自噬在宫颈癌中的相关研究进展

Related research progress of autophagy in cervical cancer cells

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