微小RNAs在涡虫再生中的研究进展

doi:10.16098/j.issn.0529-1356.2020.04.026

摘要/Abstract

摘要：

涡虫由于其体内存在丰富的成体干细胞——新母细胞（neoblasts）而具有极强的再生能力。目前，涡虫已成为再生生物学研究的重要模式动物，neoblasts也成为生物医学领域的重要工具细胞。但关于调控涡虫再生和neoblasts增殖的基因网络仍不十分清楚。微小RNAs（miRNAs）是广泛存在于真核生物中的一类内源性、小片段、非编码RNA，可通过特异性识别并结合目的RNA，负调控功能基因的表达。近期的研究提示，miRNAs可能参与涡虫再生的调控。我们就miRNAs调控涡虫再生及neoblasts，增殖和分化特性的新近研究成果及进展进行综述。

关键词: 微小RNA, 涡虫, 新母细胞, 增殖, 再生

Abstract:

Planarians have strong regenerative ability, which mainly results from the adult stem cells-neoblasts in their body. Currently, planarians have been an important model organism in the research on regeneration science, and neoblasts have also been the tool cells in biomedical research. But, the scientists still do not find the gene system that effectively regulates planarian regeneration and neoblast proliferation until now. MicroRNAs (miRNAs) are a kind of endogenous, small and noncoding RNAs widely expressed in eukaryotes. MiRNAs can negatively regulate expression of functional genes through specifically recoganizing and binding the target genes. Recently, a few studies have indicated that microRNAs may participate in planarian regeneration. In this review, we will summarize the new progress on miRNAs regulating planarian regeneration as well as neoblast proliferation and differentiation.

Key words: MicroRNA, Planarian, Neoblast, Proliferation, Regeneration

中图分类号:

Q955

张芬熙董自梅陈广文刘德增. 微小RNAs在涡虫再生中的研究进展[J]. 解剖学报, 2020, 51(4): 631-636.

ZHANG Fen-xi DONG Zi-me, CHEN Guang-wen LIU De-zeng. Progress of microRNAs in planarian regeneration[J]. Acta Anatomica Sinica, 2020, 51(4): 631-636.

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