踝蛋白与记忆机械基础理论的研究进展

doi:10.16098/j.issn.0529-1356.2023.02.019

解剖学报 ›› 2023, Vol. 54 ›› Issue (2): 249-254.doi: 10.16098/j.issn.0529-1356.2023.02.019

• 综述 • 上一篇

踝蛋白与记忆机械基础理论的研究进展

陈荟竹¹ 方璇² 陶昶煜² 张卫光^2*

1. 北京大学医学部2019级临床八年制，北京 100191； 2. 北京大学医学部基础医学院人体解剖学与组织学胚胎学系，北京 100191

收稿日期:2021-07-02 修回日期:2021-08-14 出版日期:2023-04-06 发布日期:2023-04-06
通讯作者: 张卫光 E-mail:zhangwg@bjmu.edu.cn
基金资助:
北京市自然科学基金海淀前沿项目

Progress of the talin and the mechanical basis theory of memory

CHEN Hui-zhu¹ FANG Xuan² TAO Chang-yu² ZHANG Wei-guang^2*

1. Grade 2019, Clinical Eight\|Year, Peking University Health Science Center, Beijing 100191, China; 2. Department of Human Anatomy and Histology and Embryology, School of Basic Medicine, Peking University Health Science Center, Beijing 100191, China

Received:2021-07-02 Revised:2021-08-14 Online:2023-04-06 Published:2023-04-06
Contact: ZHANG Wei-guang E-mail:zhangwg@bjmu.edu.cn

摘要/Abstract

摘要：

衰老、缺氧等诱发的记忆缺失极其普遍，因此，探索记忆的产生、存储和检索等机制对于日常生活及临床工作均具重大意义。而记忆的存储及检索或与计算机有相似之处，我们整理了记忆的机械基础-网格编码理论的研究进展。某些疾病（如阿尔茨海默病）或病理状态（如衰老、缺氧）导致的记忆缺失可能与机械敏感蛋白质踝蛋白的折叠异常有关。踝蛋白可以通过结构域状态的改变，以二进制的形式存储或更新机械力微小变化的信息，并引发神经元内配体的重新分配等化学过程，从而动态调节突触活动，将记忆以网格编码的二进制格式储存在大脑中。

关键词: 记忆, 踝蛋白, 突触, 计算机, 网格编码理论

Abstract:

Memory loss induced by aging and hypoxia is very common, so exploring the mechanism of memory production, storage and retrieval is of great significance to daily life and clinical work. The storage and retrieval of memory is probably similar to the computer. We summarized the research progress of MeshCODE theory, the mechanical basis of memory. Memory loss in certain diseases (such as Alzheimer’s disease) or pathological conditions (such as aging, lack of oxygen) may be associated with abnormal folding of talin, a mechanosensitive protein. It can dynamically regulate synaptic activity by changing the state of the domain, storing or updating information about small changes in mechanical forces in binary form, and initiating chemical processes such as ligand redistribution in neurons, so that memory is stored in the brain in a binary format, known as the MeshCODE theory.

Key words: Memory, Talin, Synapses, Computers, MeshCODE theory

中图分类号:

R318.01

陈荟竹方璇陶昶煜张卫光. 踝蛋白与记忆机械基础理论的研究进展 [J]. 解剖学报, 2023, 54(2): 249-254.

CHEN Hui-zhu FANG Xuan TAO Chang-yu ZHANG Wei-guang . Progress of the talin and the mechanical basis theory of memory[J]. Acta Anatomica Sinica, 2023, 54(2): 249-254.

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踝蛋白与记忆机械基础理论的研究进展

Progress of the talin and the mechanical basis theory of memory

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