脑膜淋巴管：联通中枢神经系统与外周免疫的门户

doi:10.16098/j.issn.0529-1356.2024.04.003

解剖学报 ›› 2024, Vol. 55 ›› Issue (4): 393-398.doi: 10.16098/j.issn.0529-1356.2024.04.003

脑膜淋巴管：联通中枢神经系统与外周免疫的门户

樊镕¹罗宇翔²高志华^2*

1.浙江大学生命科学学院，杭州 310058; 2.浙江大学脑科学与脑医学学院，杭州 310012

收稿日期:2024-03-19 修回日期:2024-05-11 出版日期:2024-08-06 发布日期:2024-08-06
通讯作者: 高志华 E-mail:zhihuagao@zju.edu.cn
基金资助:
2030科技创新“脑科学与类脑研究”重大项目;浙江省“高层次人才特殊支持计划”科技创新领军人才项目

Meningeal lymphatics: a gateway connecting the central nervous system to peripheral immune system

FAN Rong¹LUO Yu-xiang²GAO Zhi-hua^2*

1.College of Life Science, Zhejiang University, Hangzhou 310058, China; 2.School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou 310012, China

Received:2024-03-19 Revised:2024-05-11 Online:2024-08-06 Published:2024-08-06

摘要/Abstract

摘要：

传统观点认为，大脑是一个免疫豁免的独立器官。但随着研究不断深入，脑膜淋巴管的发现颠覆了这一认知，它的存在表明大脑与外周免疫之间存在着直接的物理和功能联系。脑膜淋巴管不仅参与脑脊液引流，清除脑内代谢废物，也发挥免疫监视和维持脑内免疫稳态的作用，对中枢神经系统疾病的发生发展具有重要影响，是联通脑与外周免疫系统的重要门户。本综述围绕脑膜淋巴管的解剖学结构、生理功能及其在神经系统疾病中的作用进行回顾，总结近年来的研究进展，并展望与之相关的可能研究方向与临床应用前景。

关键词: 脑膜淋巴管, 胶质淋巴系统, 中枢神经系统疾病

Abstract:

Traditionally, the brain was considered as an immune-privileged organ. However, the re-discoveries of meningeal lymphatic vessels have revolutionized our understanding, revealing direct physical and functional connections between the central nervous system and the peripheral immunity. Meningeal lymphatic vessels play a crucial role in draining cerebro-spinal fluid, clearing metabolic waste from the brain, eliciting immune surveillance and maintaining immune homeostasis within the brain. They are implicated in the pathogenesis and progression of multiple central nervous system diseases. This review mainly focuses on the anatomical structure and physiological functions of meningeal lymphatic vessels, with brief introduction to their role in neurological diseases. We summarize recent research advances in meningeal lymphatic vessels, and provide insights for further research and clinical applications.

Key words: Meningeal lymphatic vessel, Glial lymphatic system, Central nervous system disease

中图分类号:

R322.81

樊镕罗宇翔高志华. 脑膜淋巴管：联通中枢神经系统与外周免疫的门户[J]. 解剖学报, 2024, 55(4): 393-398.

FAN Rong LUO Yu-xiang GAO Zhi-hua. Meningeal lymphatics: a gateway connecting the central nervous system to peripheral immune system[J]. Acta Anatomica Sinica, 2024, 55(4): 393-398.

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脑膜淋巴管：联通中枢神经系统与外周免疫的门户

Meningeal lymphatics: a gateway connecting the central nervous system to peripheral immune system

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