解剖学报 ›› 2014, Vol. 45 ›› Issue (3): 430-436.doi: 10.3969/j.issn.0529-1356.2014.03.025

• 综述 • 上一篇    下一篇

HOX基因在肿瘤发生发展中的作用

牛苗苗 战军* 张宏权   

  1. 北京大学医学部基础医学院组织学与胚胎学教研室,北京 100191
  • 收稿日期:2013-11-05 修回日期:2013-12-12 出版日期:2014-06-06 发布日期:2014-06-06
  • 通讯作者: 战军 E-mail:zhanjun@bjmu.edu.cn
  • 基金资助:

    国家自然科学基金资助项目

Role of HOX genes in tumor genesis and development

NIU Miao-miao  ZHAN Jun*  ZHANG Hong-quan   

  1. Department of Histology and Embryology, School of Basic Medicine, Peking University,Beijing 100191, China
  • Received:2013-11-05 Revised:2013-12-12 Online:2014-06-06 Published:2014-06-06
  • Contact: ZHAN Jun E-mail:zhanjun@bjmu.edu.cn

摘要:

HOX基因是同源异形盒基因家族的一个亚家族,在进化上高度保守。HOX基因编码的蛋白是一类重要的转录因子,在胚胎发育中调节多个过程,包括细胞的生长、分化、凋亡、运动和血管生成等。近年来的研究发现,HOX基因的异常表达与恶性肿瘤密切相关。我们就有关HOX基因在肿瘤发生发展中的研究进展进行以下综述。

关键词: HOX基因, 转录因子, 肿瘤, 生物调控, 免疫组织化学

Abstract:

HOX gene belongs to a highly conserved subgroup of the homeobox superfamily. The HOX genes constitute a family of transcription factors that play key roles in embryonic development, regulating numerous processes, such us cellular growth, differentiation, apoptosis, motility and angiogenesis. The present review shows that there is a close relationship between aberrant expression of HOX genes and malignancy. This article summarizes briofly the advances in the research on HOX genes and their roles in tumor genesis.

Key words: HOX gene, Transcription factor, Tumor, Biological regulation, Immunohistochemistry