rDNA在细胞发育中的转录及调控

doi:10.16098/j.issn.0529-1356.2018.05.023

解剖学报 ›› 2018, Vol. 49 ›› Issue (5): 695-698.doi: 10.16098/j.issn.0529-1356.2018.05.023

rDNA在细胞发育中的转录及调控

李佳王琪宮甜甜张玥单智焱* 雷蕾

哈尔滨医科大学组织学与胚胎学教研室，哈尔滨 150081

收稿日期:2017-09-20 修回日期:2017-11-21 出版日期:2018-10-06 发布日期:2018-10-06
通讯作者: 单智焱 E-mail:shanzhiyan1979@126.com
基金资助:
组蛋白变体H3.3掺入rDNA异染色质在体细胞重编程中的作用研究;黑龙江省博士后科研启动金

Transcription and regulation of rDNA in cell development

LI Jia WANG Qi GONG Tian-tian ZHANG Yue SHAN Zhi-yan* LEI Lei

Department of Histology and Embryology, Harbin Medical University, Harbin 150081, China

Received:2017-09-20 Revised:2017-11-21 Online:2018-10-06 Published:2018-10-06
Contact: SHAN Zhi-yan E-mail:shanzhiyan1979@126.com

摘要/Abstract

摘要：

细胞的生长发育受核糖体DNA(rDNA)和蛋白质基因的协同调控，细胞总RNA的85%是rDNA的转录产物。rDNA的转录改变会导致核糖体生物合成应激，影响细胞的生长、增殖和分化，导致疾病的发生。理解rDNA的转录调控有利于阐明细胞发育的机制，找到治疗疾病的新的作用靶点。我们综述了rDNA的结构及转录调控方式，阐述了rDNA在干细胞领域和疾病发生治疗中的作用，为rDNA的研究提供理论依据。

关键词: rDNA, 细胞发育, 调控

Abstract:

The growth and development of cells are regulated by ribosome DNA(rDNA) and protein gene. Eighty-five percent of the total RNA is the transcription product of rDNA. Changes in rDNA transcription may lead to ribosomal biosynthesis stress, which affects cells growth, proliferation and differentiation, and further leads to the occurrence of diseases. Revealing the mechanism of rDNA transcriptional regulation is helpful to further elucidate the mechanism of cell development and find a new target for the treatment of diseases. In this paper, we describe the structure of rDNA and its transcriptional regulation,and discuss the roles of rDNA on the stem cells and occurring, treatment of disease, which provides a theoretical basis for rDNA in clinical research.

Key words: rDNA, Cell development, Regulation

李佳王琪宮甜甜张玥单智焱雷蕾. rDNA在细胞发育中的转录及调控[J]. 解剖学报, 2018, 49(5): 695-698.

LI Jia WANG Qi GONG Tian-tian ZHANG Yue SHAN Zhi-yan LEI Lei. Transcription and regulation of rDNA in cell development[J]. Acta Anatomica Sinica, 2018, 49(5): 695-698.

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rDNA在细胞发育中的转录及调控

Transcription and regulation of rDNA in cell development

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