男性精神分裂症的指长比特征

doi:10.16098/j.issn.0529-1356.2023.04.014

解剖学报 ›› 2023, Vol. 54 ›› Issue (4): 473-476.doi: 10.16098/j.issn.0529-1356.2023.04.014

男性精神分裂症的指长比特征

牛世博^1,2 杨梦怡^1,2徐彧^1,2党洁1^,2马占兵^1,2 霍正浩^1,2 陆宏^1,2*

1.宁夏医科大学基础医学院，银川 750004; 2.宁夏医科大学教育部生育力保持省部共建重点实验室，银川 750004

收稿日期:2022-05-23 修回日期:2022-07-19 出版日期:2023-08-06 发布日期:2023-08-06
通讯作者: 陆宏 E-mail:chuan773@126.com
基金资助:
国家自然科学基金

Digit ratio in men with schizophrenia

NIU Shi-bo^1,2YANG Meng-yi^1,2 XU Yu^1,2DANG Jie^1,2 MA Zhan-bing^1,2 HUO Zheng-hao^1,2 LU Hong^1,2*

1.Basic Medical College, Ningxia Medical University, Yinchuan 750004,China; 2.Key Laboratory of Fertility Preservation and
Maintenance of Ministry of Education, Ningxia Medical University, Yinchuan 750004,China

Received:2022-05-23 Revised:2022-07-19 Online:2023-08-06 Published:2023-08-06
Contact: LU Hong E-mail:chuan773@126.com

摘要/Abstract

摘要：

目的探讨指长比与宁夏汉族男性精神分裂症的关系。方法采用体质测量法，数码相机提取216例男性受试者（正常对照：116例，精神分裂症患者：100例）指长照片，计算机图像分析软件（Image-Pro plus 6.0）标记解剖点并测量双手各指指长，比较对照组和患者组左手及右手2D∶3D、2D∶4D、2D∶5D、3D∶4D、3D∶5D、4D∶5D指长比均值的差异性，分析2D∶4D与患者组发病年龄的相关性。结果除左手和右手3D∶4D外，患者组双手各指长比均显著高于对照组（双手2D∶4D和2D∶5D，右手3D∶5D，P均<0.001；双手2D∶3D和4D∶5D及左手3D∶5D，P 均<0.01）；与对照组相比（左手：1%，右手：1%），患者组（左手：6%，右手：7%）2D∶4D ≥1的人数比例均显著增高（P <0.05）；患者组2D∶4D均值与发病年龄无相关性（P >0.05）。结论指长比与宁夏汉族男性精神分裂症的发生有关。

关键词: 指长比, 精神分裂症, 男性, 体质测量法, 成人

Abstract:

Objective To investigate the relationship between digit ratio and schizophrenia in men from Ningxia Han nationality. Methods Using anthropometry, digital camera was used to obtain finger photographs of both hands of 216 male subjects (normal control: 116, schizophrenia patient: 100). The anatomical points were marked and the length of each finger of both hands were measured by computer image analysis software (Image-Pro Plus 6.0). Differences of the mean digit ratio of left and right hand 2D∶3D, 2D∶4D, 2D∶5D, 3D∶4D, 3D∶5D, 4D∶5D between the control group and the patient group were compared. The correlation between 2D∶4D and onset age in the patient group were analyzed. Results Except for left and right hand 3D∶4D, digit ratios in patient group were significantly higher than those in control group (2D∶4D and 3D∶5D in both hands, right hand 3D∶5D, p all<0.001; 2D∶3D and 4D∶5D, left hand 3D∶5D, P <0.01). Compared with the control group (left hand: 1%, right hand: 1%), the percentage of 2D∶4D ≥1 were significantly higher (P <0.05) in the patient group (left hand: 6%, right hand: 7%). There were no correlations between 2D∶4D mean value and onset age in patients group (P >0.05). Conclusion Digit ratio is related to the occurrence of schizophrenia in Ningxia Han male.

Key words: Digit ratio, Schizophrenia, Male, Anthropometry, Adult

中图分类号:

Q983

牛世博杨梦怡徐彧党洁马占兵霍正浩陆宏 . 男性精神分裂症的指长比特征[J]. 解剖学报, 2023, 54(4): 473-476.

NIU Shi-bo YANG Meng-yi XU Yu DANG Jie MA Zhan-bing HUO Zheng-hao LU Hong . Digit ratio in men with schizophrenia[J]. Acta Anatomica Sinica, 2023, 54(4): 473-476.

参考文献

［1］Winship IR, Dursun SM, Baker GB, et al. An overview of animal models related to schizophrenia［J］. Can J Psychiatry, 2019, 64(1): 5-17.

[2］Swaab DF, Wolff S, Bao AM. Sexual differentiation of the human hypothalamus: relationship to gender identity and sexual orientation［J］. Handb Clin Neurol, 2021, 181(1): 427-443.

［3］Marrocco J, Mcewen BS. Sex in the brain: hormones and sex differences［J］. Dialogues Clin Neurosci, 2016, 18(4): 373-383.

［4］Manning JT. Resolving the role of prenatal sex steroids in the development of digit ratio［J］. Proc Natl Acad Sci USA, 2011,108(39):16143-16144.

［5］Arato M, Frecska E, Beck C, et al. Digit length pattern in schizophrenia suggests disturbed prenatal hemispheric lateralization［J］. Prog Neuro psychopharmacol Biol Psychiatry, 2004, 28(2): 191-194.

［6］Walder DJ, Andersson TL, Mcmillan AL, et al. Sex differences in digit ratio (2D∶4D) are disrupted in adolescents with schizotypal personality disorder: altered prenatal gonadal hormone levels as a risk factor［J］. Schizophr Res, 2006, 86(1-3): 118-122.

［7］Collinson SL, Lim M, Chaw JH, et al. Increased ratio of 2nd to 4th digit (2D∶4D) in schizophrenia［J］. Psychiatry Res, 2018,176 (2): 8-12.

［8］Daly MP, Gooding DC, Jessen HM, et al. Indicators of developmental deviance in individuals at risk for schizophrenia［J］. Schizophr Res, 2008, 101(1-3): 152-160.

［9］Gooding DC, Johnson M, Peterman JS. Schizotypy and altered digit ratio: a second look［J］. Psychiatry Res, 2010,30 (1): 73-78.

［10］Venkatasubramanian G, Arasappa R, Rao NP, et al. Digit ratio (2D∶4D) asymmetry and schneiderian first rank symptoms: implications for cerebral lateralisation theories of schizophrenia［J］. Laterality, 2011,16 (3):499-512.

［11］Nieuwoudt W, Smit IM, Niehaus D, et al. Digit ratio as an endophenotype in a schizophrenia population［J］. S Afr J Psychiatr, 2021, 279(1): 1587-1592.

［12］Psychosis Branch of Chinese Medical Association. The Chinese Classification and the Diagnose Criterion of Mental Disorder (CCMD-3) ［M］．3th, ed．Ji’nan: Shandong Technology Press, 2001: 47-76. (in Chinese)

中华医学会精神科分会．中国精神疾病分类方案与诊断标准第3版(CCMD-3)［M］．第3版．济南: 山东科学技术出版社, 2001:47-76.

［13］Zhanbing M, Jie D, Chunyue B, et al. Association of CYP19A1 single-nucleotide polymorphism with digit ratio (2D∶4D) in a sample of men and women from Ningxia (China) ［J］. Early Hum Dev, 2019, 132(4): 58-65.

［14］Xi HJ，Zhao H，Li WH，et al．Primary analysis of current studies on the digit ratio［J］．Acta Anatomica Sinica，2012, 43 (4): 569-573．(in Chinese)

席焕久, 赵红，李文慧，等. 对指长比研究现状的初步分析［J］．解剖学报，2012, 43(4): 569-573.

［15］Markham JA. Sex steroids and schizophrenia［J］. Rev Endocr Metab Disord, 2012, 13(3):187-207.

［16］Marenco S, Weinberger DR. The neurodevelopmental hypothesis of schizophrenia: following a trail of evidence from cradle to grave［J］. Dev Psychopathol, 2000,12(3):501-527.

［17］Manning JT, Baron-Cohen S, Wheelwright S, et al. The 2nd to 4th digit ratio and autism［J］. Dev Med Child Neurol, 2001, 43(3): 160-164.

［18］Schieve LA, Tian L, Dowling N, et al. Associations between the 2nd to 4th digit ratio and autism spectrum disorder in population-based samples of boys and girls: findings from the study to explore early development［J］. J Autism Dev Disord, 2018, 48(7): 2379-2395.

［19］Lee S, Aziz SA, Hamid M, et al. 2D∶4D ratio and autism spectrum disorder in Brunei Darussalam［J］. J Autism Dev Disord, 2021, 51(12): 4577-4586.

［20］Zheng Z, Cohn MJ. Developmental basis of sexually dimorphic digit ratios［J］. Proc Natl Acad Sci USA, 2011, 108(39):16289-16294.

［21］Mcewen BS, Milner TA. Understanding the broad influence of sex hormones and sex differences in the brain［J］. J Neurosci Res, 2017, 95(1-2): 24-39.

［22］Manning JT, Callow M, Bundred PE. Finger and toe ratios in humans and mice: implications for the aetiology of diseases influenced by HOX genes［J］. Med Hypotheses, 2003, 60(3): 340-343.

［23］Eichler A, Heinrich H, Moll GH, et al. Digit ratio (2D∶4D) and behavioral symptoms in primary-school aged boys［J］. Early Hum Dev, 2018, 119(4): 1-7.

［24］Manning JT, Bundred PE, Kasielska-Trojan A, et al. Digit ratio (2D∶4D), myocardial infarction and fibrinogen in men［J］. Early Hum Dev, 2019, 133(6): 18-22.

［25］Bolu A, Oznur T, Develi S, et al. The ratios of 2nd to 4th digit may be a predictor of schizophrenia in male patients［J］. Clin Anat, 2015, 28(4): 551-556.

［26］Fusar-Poli L, Rodolico A, Sturiale S, et al. Second-to-fourth digit ratio (2D∶4D) in psychiatric disorders: a systematic review of case-control studies［J］. Clin Psychopharmacol Neurosci, 2021, 19(1): 26-45.

[1]	杨梦怡牛世博张静党洁马占兵陆宏霍正浩. 宁夏大学生示指和环指指长比与同源盒A11基因位点多态性的关联性 [J]. 解剖学报, 2024, 55(1): 62-66.
[2]	袁硕赵安全黄其日麦拉图吴海贺徐永胜齐岩松包呼日查 . 基于下肢全长CT分析胫骨平台后倾角和胫骨扭转角与复发性髌骨脱位的相关性 [J]. 解剖学报, 2023, 54(6): 703-709.
[3]	王子善张兴华徐飞宇克莉郑连斌程瑜 . 云南布朗族、德昂族、佤族营养体格指数、肥胖状况及其高血压预警 [J]. 解剖学报, 2023, 54(6): 730-737.
[4]	白芃李玮钟铧王展飞. 藏族正常成人头颅正中矢状面幕上和幕下面积的磁共振成像测量[J]. 解剖学报, 2023, 54(5): 567-574.
[5]	刘建朱光琼刘坤祥 . 成人肘肌肌构筑学及肌内神经分布模式[J]. 解剖学报, 2023, 54(5): 582-585.
[6]	徐国昌陈志国温有锋姜东郭克磊. 锡伯族成人6项身体指数与分型特征[J]. 解剖学报, 2023, 54(4): 477-483.
[7]	罗艳萍刘潮谷嬉嬉陈健明蓝艳韦叶生. 广西壮族人群微小RNA-30基因多态性分布特征及其与血脂水平的关系[J]. 解剖学报, 2023, 54(4): 400-404.
[8]	杨晨王露飞乔辉祝海歌文少卿张航谭婧泽. 汉族和壮族人群牙齿非测量表型特征[J]. 解剖学报, 2023, 54(3): 357-367.
[9]	廉祎李咏兰于会新 . 贵州苗族与湘西苗族体成分分析[J]. 解剖学报, 2023, 54(2): 231-237.
[10]	李甲一席焕久温有锋桂超张晓明张海龙 . 辽宁省汉族成人少肌症、少肌性肥胖与骨质疏松症的相关性[J]. 解剖学报, 2023, 54(2): 238-243.
[11]	李帆马占兵张静杨梦怡王媛马茜陆宏霍正浩党洁 . 羟基类固醇脱氢酶基因家族单核苷酸多态性与指长比的关联性[J]. 解剖学报, 2023, 54(2): 208-215.
[12]	徐高磊刘锦易诗琦张译铮张振华 . 肱二头肌短头近端起源部位的解剖学特征[J]. 解剖学报, 2023, 54(2): 216-219.
[13]	高雯芳郑连斌徐飞张兴华宇克莉. 中国藏缅语族17个民族成人的体部特征[J]. 解剖学报, 2023, 54(1): 104-112.
[14]	李咏兰郑连斌. 中国蒙古族青年到老年的容貌变化特征[J]. 解剖学报, 2022, 53(6): 793-801.
[15]	黄婷李欣兰蕙温有锋. 哈萨克族舌运动类型及其相互关系[J]. 解剖学报, 2022, 53(6): 802-807.

男性精神分裂症的指长比特征

Digit ratio in men with schizophrenia

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价