Parthanatos involved in tubular damages of the kidney in rats with type 2 diabetics

doi:10.3969/j.issn.0529-1356.2013.03.023

Abstract

Abstract:

Objective To observe the parthanatos involved in tubular cell damages of kidney in rats with type 2 diabetics.
Methods Animal models of type 2 diabetics were established. Light microscopy, electron microscopy, immunohistochemistry and
Western blotting were used in this study. Results A large number of glycogen accumulation, cell swelling, and partial necrosis,
mainly for the vacuolar necrosis were seen in early type 2 diabetes renal tubular cells. Immunohistochemical staining of PARP-1
showed that the positive cells were found in epithelium of renal tubules of type 2 diabetic kidney. Compared to the control
kidney, PARP-1 expressed much stronger by immunoblot analysis. Conclusion Necrosis and parthanatos are involved in renal tubule
damages induced by type 2 diabetes in rats.

Key words: Type 2 diabetes mellitus, Renal tubule damage, Necrosis, Parthanatos, Immunohistochemistry, Western blotting, Rat

LI Shu-ling YAN Wen-zhu*. Parthanatos involved in tubular damages of the kidney in rats with type 2 diabetics[J]. AAS, 2013, 44(3 ): 409-412.

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