AAS ›› 2014, Vol. 45 ›› Issue (3): 437-440.doi: 10.3969/j.issn.0529-1356.2014.03.026

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Role of phosphorylation of p53 at Ser392 in cancer therapy

LIU Jing-li1 SHI Xin-li1 CUI Cheng1 REN Lai-feng3 ZHENG Wen-guang1 LI Ming-yuan 4*   

  1. 1. Department of Repairing and Servicing Technology of Medical Equipment, Bethune Medical NonCommissioned Officer Academy of PLA, Shijiazhuang 050081, China;2. Academic Affairs Office, Hebei University of Chinese Medicine,Shijiazhuang 050200, China;3. Department of Medical Laboratory Science, Fenyang College of Shanxi Medical University, Shanxi Linfen 032200, China;4. Department of Microbiology, College of Basic and Forensic Medicine, Sichuan University, Chengdu 610041, China)
     
  • Received:2013-10-17 Revised:2014-02-21 Online:2014-06-06 Published:2014-06-06
  • Contact: LI Ming-yuan E-mail:sxlsunshine@sina.com

Abstract:

Phosphorylation is the most common way of p53 post-translational modifications. However, gaps still exist in our knowledge regarding the role and mechanism of phosphorylation of p53 at Ser392 in carcinogenesis and cancer prevention. In the present study, we summarized the effect of phos-p53-Ser392 to wild-type and mutant p53, the regulation by DNA damage agents and protein kinase, and the significance of phosphorylation of p53-Ser392 in cancer treatment.

Key words: p53, Ser392, Phosphorylation, Cancer therapy, Gene mutant, Western blotting