Role of Nogo-A and Nogo-A receptors in Alzheimer’s disease

doi:10.16098/j.issn.0529-1356.2018.04.023

Abstract

Abstract:

Nogo-A is an important myelin associated inhibitory factor, which creates a critical barrier to the central nervous system regeneration after injury. Recent research shows that Nogo-A/Nogo-A receptors can affect the metabolism of amyloid-β-protein (Aβ), and its downstream ROCK kinase. It can modulate the level of Aβ and tau protein, as well as the permeability of blood brain barrier. These findings suggest that Nogo-A/Nogo-A receptors have a close relationship with Alzheimer’s disease (AD). Moreover, two new receptors of Nogo-A, PirB and S1PR2, have been identified recently. The identification of these two receptors may provide new insight into the mechanism of Nogo-A involving in the progress of central nervous diseases. we focuses on the up-to-date knowledge of the basic structure and function of Nogo-A/Nogo-A receptors and their role in AD pathogenesis.

Key words: Nogo-A, Alzheimer’s disease, Neurodegenerative disease

WANG Zhao-lun ZHANG Yan WANG Jun. Role of Nogo-A and Nogo-A receptors in Alzheimer’s disease[J]. Acta Anatomica Sinica, 2018, 49(4): 549-555.

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