Research progress of janus kinase - signal transducers and activators of transcription signal transduction pathway and neurogenesis

doi:10.16098/j.issn.0529-1356.2019.05.024

Abstract

Abstract:

Janus kinase-signal transducers and activators of transcription (JAK-STAT) signal transduction pathway is related to cellular biological activities and occurrence and development of many diseases. In recent years, JAK-STAT signal transduction pathway has been found in the central nervous system to regulate neurodegenerative diseases and nerve regeneration after nerve injury；however, promoting endogenous neurogenesis as a new direction of nerve regeneration research is also closely related to the positive or negative regulation of JAK-STAT signal transduction pathway. This article reviews the research progress of JAK-STAT signal transduction pathway, neurogenesis, and JAK-STAT signal transduction pathway regulating neurogenesis.

Key words: Janus kinase, Signal transducers and activators of transcription, Neurogenesis

LIU Kuang-pin MA Wei YANG Jin-wei DAI Yun-fei GUO Jian-hui LI Li-yan.

Research progress of janus kinase - signal transducers and activators of transcription signal transduction pathway and neurogenesis

[J]. Acta Anatomica Sinica, 2019, 50(5): 684-689.

References

［1］ Nicolas CS, Amici M, Bortolotto ZA, et al. The role of JAK-STAT signaling within the CNS ［J］. JAKSTAT, 2013, 2(1):e22925.

［2］ Yang X, Chung D, Cepko CL. Molecular cloning of the murine JAK1 protein tyrosine kinase and its expression in the mouse central nervous system ［J］. J Neurosci, 1993, 13 (7):3006-3017.

［3］ Sánchez MP, Tapley P, Saini SS, et al. Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain ［J］. Proc Natl Acad Sci USA, 1994, 91 (5):1819-1823.

［4］ Bonni A, Sun Y, Nadalvicens M, et al. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway［J］. Science, 1997, 278(5337):477-483.

［5］ Lee CH, Tan KL, Cheah PS, et al. Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in down syndrome Brain ［J］. Neural Plasticity, 2016, 2016(11):7434191-7434202.

［6］ Gauzzi MC, Velazquez L, Mckendry R, et al. Interferon-dependent activation of TYK2 requires phosphorylation of positive regulatory tyrosines by another kinase［J］. J Biol Chem, 1996, 271 (34):20494-20500.

［7］ Feng J, Witthuhn BA, Matsuda T, et al. Activation of JAK2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop ［J］. Mol Cell Biol, 1997, 17 (5):2497-2501.

［8］ Fujitani Y, Hibi M, Fukada T, et al. An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT［J］. Oncogene, 1997, 14(7):751-761.

［9］ Frank SJ, Gilliland G, Kraft AS, et al. Interaction of the growth hormone receptor cytoplasmic domain with the JAK2 tyrosine kinase［J］. Endocrinology, 1994,135(5):2228-2239.

［10］Duhé RJ, Farrar WL.Structural and mechanistic aspects of Janus kinases: how the two-faced god wields a double-edged sword ［J］. J Interferon Cytokine Res, 1998,18 (1):1-15.

［11］Quelle FW, Sato N, Witthuhn BA, et al. JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requiresthe membrane-proximal region ［J］. Mol Cellr Biol,1994,14(7):4335-4341.

［12］Lai CF, Ripperger J, Morella KK, et al. Separate signaling mechanisms are involved in the control of STAT protein activation and gene regulation via the interleukin 6 response element by the box 3 motif of gp130 ［J］. J Biol Chem, 1995, 270 (25):14847-14850.

［13］Rawlings JS, Kristin M, Rosler, et al. The JAK/STAT signaling pathway［J］. J Cell Sci, 2004,117 (8):1281-1283.

［14］Defraja C, Conti L, Magrassi L, et al. Members of the JAK/STAT proteins are expressed and regulated during development in the mammalian forebrain［J］. J Neurosci Res, 1998,54(3):320-330.

［15］Kim YH, Chung JI, Woo HG, et al. Differential regulation of proliferation and differentiation in neural precursor cells by the JAK pathway［J］. Stem Cells, 2010, 28(10): 1816-182.

［16］Defraja C, Conti L, Govoni S, et al. STAT signalling in the mature and aging brain［J］. Int J Dev Neurosci, 2000，18(4-5):439-446.

［17］Yao B, Jin P. Unlocking epigenetic codes in neurogenesis［J］. Genes Dev, 2014，28(12):1253-1271.

［18］Yoshimatsu T, Kawaguchi D, Oishi K, et al. Non-cell-autonomous action of STAT3 in maintenance of neural precursor cells in the mouse neocortex［J］. Development, 2006,133(13):2553-2563.

［19］Jebbett NJ, Hamilton JW, Rand MD, et al. Low level Methylmercury enhances CNTF-evoked STAT3 signaling and glial differentiation in cultured cortical progenitor cells ［J］. Neurotoxicology, 2013,38（4）: 91-100.

［20］Nakanishi M, Niidome T, Matsuda S, et al. Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells［J］. Eur J Neurosci, 2010, 25 (3):649-658.

［21］Kohyama J, Kojima T, Takatsuka E, et al. Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain［J］. Proc Natl Acad Sci USA, 2008, 105(46):18012-18017.

［22］Bauer S. Cytokine control of adult neural stem cells chronic versus acute exposure［J］. Ann NY Acad Sci, 2009,1153(1):48-56.

［23］Diego GN, Beatriz VA, Noemí PB, et al. Interleukin-15 regulates proliferation and self-renewal of adult neural stem cells［J］. Mol Biol Cell, 2011, 22 (12):1960-1970.

［24］Garza JC, Guo M, Zhang W, et al. Leptin increases adult hippocampal neurogenesis in vivo and in vitro［J］. J Biol Chem, 2008, 283 (26):18238-18247.

［25］Nicolas CS, Peineau S, Amici M, et al. The JAK/STAT pathway is involved in synaptic plasticity［J］. Neuron, 2012, 73 (2):374-390.

［26］Peng H, Whitney N, Wu Y, et al. HIV-1-infected and/or immune-activated macrophage-secreted TNF-alpha affects human fetal cortical neural progenitor cell proliferation and differentiation［J］. Glia, 2010, 56 (8):903-916.

［27］Li Q, Qin LH, Luan LJ, et al. Influence of neuregulin on neuronal apoptosis and expressions of STAT3 and GFAP following cerebral ischemic reperfusion injury in rats［J］. Acta Anatomica Sinica,2008,39（6）：820-825.（in Chinese）

李琴，秦丽华，栾丽菊，等.神经调节素对大鼠脑缺血再灌注损伤细胞凋亡和STAT3及GFAP表达的影响［J］.解剖学报，2008，39（6）：820-825.

［28］Chen E, Xu D, Lan X, et al. A Novel Role of the STAT3 Pathway in Brain Inflammation-induced Human Neural Progenitor Cell Differentiation［J］. Curr Mol Med, 2013,13(9): 1474-1484.

［29］Ito H, Nakajima A, Nomoto H, et al. Neurotrophins facilitate neuronal differentiation of cultured neural stem cells via induction of mRNA expression of basic helix-loop-helix transcription factors Mash1 and Math1［J］. J Neurosci Res, 2003,71(5):648-658.

［30］Fukuda S, Taga T. Cell fate determination regulated by a transcriptional signal network in the developing mouse brain ［J］. Anat Sci Int, 2015, 80 (1):12-18.

［31］Nakashima K, Wiese S, Yanagisawa M, et al. Developmental requirement of gp130 signaling in neuronal survival and astrocyte differentiation［J］. J Neurosci, 1999, 19(13):5429-5434.

［32］Freed CR, Greene PE, Breeze RE, et al. Transplantation of embryonic dopamine neurons for severe Parkinson’s disease［J］. N Engl J Med, 2001, 344(10): 710-719.

［33］Zhu P, Hata R, Cao F, et al. Ramified microglial cells promote astrogliogenesis and maintenance of neural stem cells through activation of STAT3 function［J］. Faseb J, 2008, 22(11):3866-3877.

［34］Smith RP, Lerchhaner JK, Pardinas JR, et al. Transcriptional profiling of intrinsic PNS factors in the postnatal mouse［J］. Mol Cell Neurosci, 2011,46 (1):32-44.

［35］Benito C, Davis CM, Gomezsanchez JA, et al. STAT3 controls the long-term survival and phenotype of repair schwann cells during nerve regeneration［J］. J Neurosci, 2017, 37(16):4255-4269.

［36］Xu JJ, Chen EY, Lu CL,et al. Effects of recombinant ciliary neurotrophic factor on STAT3 expression and tyrosine phosphorylation in the injured neurons during peripheral nerve regeneration［J］. Acta Anatomica Sinica, 2003,34(3):241-245.(in Chinese)

许家军,陈尔瑜,路长林，等. 周围神经再生时重组CNTF对受损神经元STAT3表达和酪氨酸酸化的作用［J］.解剖学报,2003,34(3):241-245.

［37］Martynoga B, Drechsel D, Guillemot F. Molecular control of neurogenesis: a view from the mammalian cerebral cortex［J］. Cold Spring Harb Perspect Biol, 2012, 4 (10):759-769.

［38］Rong Y, Ren FL, Ning HX, et al. SIPAR expression pattern during development of mouse embryo detected by whole mount in situ hybridization［J］. Acta Anatomica Sinica，2006，37（2）：121-124. (in Chinese)

戎煜,任芳丽,宁红秀,等. 利用原位杂交技术研究SIPAR在小鼠不同发育阶段的表达［J］.解剖学报，2006，37（2）：121-124.

［39］Kamakura S, Oishi K, Yoshimatsu T, et al. Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling［J］. Nat Cell Biol, 2004, 6 (6):547-554.

［40］Wang T, Yuan W, Liu Y, et al. The role of the JAK-STAT pathway in neural stem cells, neural progenitor cells and reactive astrocytes after spinal cord injury［J］. Biomed Rep, 2015, 3 (2):141-146.

[1]	HE Ke-ke LI Yuan-di WEN Ting-hao ZHU Jie GAO Jie HU Rong HAN Feng SU Min . Erythrocyte membrane-associated protein inhibiting Th17 cell differentiation via IL-6/STAT3/ROR-γt signaling pathway in experimental autoimmune encephalomyelitis mice encephalomyelitis mice [J]. Acta Anatomica Sinica, 2023, 54(5): 538-545.
[2]	WANG Ya-juan YANG Bin ZENG Xue-qing LIANG Yue LIU Zhi-wen CAO Wen-yu ZHONG Xiao-lin . Dexmedetomidine improving complete Freund’s adjuvant-induced anxiety-like and depression-like behaviour by promoting the expression of brain-derived neurotrophic factor-tyrosin kinase receptor B in mice hippocampus [J]. Acta Anatomica Sinica, 2023, 54(2): 181-187.
[3]	LI Rui-ting LEI Ling-feng YANG Na XIANG Zhi-yu LI Ze-kai LU Li . Impaired cholesterol metabolism affecting subventricular zone neurogenesis in ob/ob mice [J]. Acta Anatomica Sinica, 2023, 54(2): 165-174.
[4]	LU Fen YANG Qing SHAO Wen-jun SUN Zhen-kun WANG En-man ZHANG Wei-na. Protective effects of micro RNA-98-5p targeting Kruppel-like factor 9 against myocardial ischemia-reperfusion injury in rats [J]. Acta Anatomica Sinica, 2022, 53(3): 347-353.
[5]	LI Wei ZHOU Xin XIE Zhi-yan ZHANG Tian-le YANG Hui CAO Wen-yu LIU Zhi-wen ZENG Jia-yu. Voluntary wheel running prevents the formaldehyde induced negativeemotion through up-regulation of hippocampal neurogenesis in mice#br# [J]. Acta Anatomica Sinica, 2021, 52(5): 686-691.
[6]	ZOU Lin-qing YI Xin HE Hui SHAN Bo-quan JIN Guo-hua LI Hao-ming. Expression of RUNX1T1 and neuronal differentiation in radial glial cells after deafferented injury of hippocampus in vitro [J]. Acta Anatomica Sinica, 2020, 51(6): 809-814.
[7]	DING Yan-ping JIN Yi-ran BAI Yu-jie PAN Zi-yan SHAO Bao-ping. Regulation of neuroimmune system on learning and memory [J]. Acta Anatomica Sinica, 2018, 49(4): 543-548.
[8]	LI Xia LI Shu-qing. Regulation of ischemic postconditioning on signal transducers and activators of transcription 3 hyperphosphorylation after cerebral ischemia in tree shrews [J]. Acta Anatomica Sinica, 2018, 49(2): 143-150.
[9]	XIE Ming-qi CHEN Zhi-chi WANG Tong-tong ZHOU Xiang HUANG Hou-ju QI Shuang-shuang LIAO Min SUN Chen-you. Current status of neurogenesis in neurotoxin-induced animal models for Parkinson’s disease [J]. Acta Anatomica Sinica, 2017, 48(5): 610-616.
[10]	YANG Qian-qian ZHANG Peng DAI Kan-chun WANG Jia-ting SUN Chen-you. Actions of neurosteroids in neurons and the treatment of neurodegenerative disease [J]. AAS, 2014, 45(3): 424-429.
[11]	WANG Qiong-sa, QI Shuang-shuang, ZHOU Peng, ZHANG Chi-hao, CUI Huai-rui, CHEN Shi-xin, SUN Chen-you* . Effect of allopregnanolone on the dopaminergic neurons in the substantia nigra of Alzheimer’s disease mice  [J]. AAS, 2013, 44(2 ): 176-181.
[12]	. Insulin-like growth factor 1 playing a pivotal role on recovery of transient forebrain ischemia damage in neonatal rats [J]. , 2012, 43(2): 145-149.
[13]	. Effects of transient hypoxia on apoptosis and neurogenesis in the newborn rat brain [J]. , 2011, 42(6): 741-745.
[14]	. Expression of neurogenic differentiation factor increased after transient hypoxia of hippocampal neurons EM>in vitro/EM> [J]. , 2011, 42(1): 27-31.
[15]	. Relationship of the epilepsy induced by IL-2 and JAK/STATs signal transduction pathway [J]. , 2009, 40(1): 73-77.