解剖学报

›› 2012, Vol. 43 ›› Issue (3): 422-424.doi: 10.3969/j.issn.0529-1356.2012.03.024

• 人类学 • 上一篇    下一篇

ApoE基因多态性对毛南族人群血清apoA1、apoB水平的影响

郭启燕1; 龙思方1; 范平 2* ; 白怀2; 王芳2   

  1. 1.贵州省黔南民族医学高等专科学校生物化学教研室，贵州 558000; 2.四川大学华西第二医院遗传代谢性疾病及围生医学实验室，成都610041
  • 收稿日期:2011-07-17 修回日期:2011-09-16 出版日期:2012-06-06
  • 通讯作者: 范平

Effects of apoE polymorphism on serum apoA1 and apoB levels in Maonan ethnic minority

  1. 1.Department of Biochemistry, the High Medical College of Qiannan,Guizhou 558000,China; 2.Laboratory of Genetic Disease and Perinatal Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041,China
  • Received:2011-07-17 Revised:2011-09-16 Online:2012-06-06
  • Contact: FAN Ping

关键词: 基因多态性, 载脂蛋白E, 载脂蛋白A1, 载脂蛋白B, 免疫透射比浊法, 毛南族

Abstract: Objective To investigate effects of apolipoprotein (apo) E polymorphism on serum apoA1 and apoB levels in Maonan ethnic group. Methods Serum apoA1 and apoB concentrations were measured in 221 healthy subjects from a population of Maonan ethnic group in Qiannan autonomous area of Guizhou province using immunoturbidimetric assay. ApoE2,E3,E4 genotypes were determined by polymerase chain reactionrestriction fragment length polymorphisms (PCR-RFLPs). Results Increased apoB levels and decreased apoA1-to-apoB ratio were found in carriers with apoE4 isoform (E3/4+E4/4) ( n =41) and apoE3/3 homozygotes ( n =143) as compared to carriers with apoE2 isoform (E2/2+E2/3+ E2/4) ( n =37, P <0.05). ApoB levels were higher in carriers with apoE4 isoform than those with apoE3/3 homozygotes ( P <0.05). No significant differences were found for apoA1 levels among the groups mentioned above ( P >0.05). Conclusion This study suggests that apoE polymorphism is associated with serum apoB levels and apoA1/B ratio, but not with apoA1 levels, in Maonan e

Key words: Genetic polymorphism, Apolipoprotein E, Apolipoprotein A1, Apolipoprotein B, Immunoturbidimetric assay, Maonan nationality

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