解剖学报

解剖学报 ›› 2020, Vol. 51 ›› Issue (6): 897-905.doi: 10.16098/j.issn.0529-1356.2020.06.014

• 肿瘤生物学 • 上一篇    下一篇

一种新的乳腺癌预后标志物——着丝粒蛋白M

晁晓钰 郭莹 李祥会 吴素霞 厉永强* 石贞玉*    

  1. 河南大学基础医学院医学生物信息学研究所，河南 开封 475004
  • 收稿日期:2019-09-04 修回日期:2020-06-19 出版日期:2020-12-06 发布日期:2020-12-06
  • 通讯作者: 厉永强;石贞玉 E-mail:976201697@qq.com
  • 基金资助:
    河南省科技发展计划项目;河南省科技发展计划项目

Centromere protein M: a novel biomarker for prognosis of human breast cancer#br#

CHAO Xiao-yu  GUO Ying  LI Xiang-hui  WU Su-xia  LI Yong-qiang*  SHI Zhen-yu*   

  1. Institute of Biomedical Informatics, School Basic Medical Sciences, He’nan University， He’nan Kaifeng 475004，China
  • Received:2019-09-04 Revised:2020-06-19 Online:2020-12-06 Published:2020-12-06
  • Contact: LI Yong-qiang;SHI Zhen-yu E-mail:976201697@qq.com

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摘要：

目的  着丝粒蛋白M（CENP-M）是组成型着丝粒相关网络（CCAN）蛋白家族的一名重要成员，它可以保证着丝粒、动粒的正确形成和功能行使，在细胞正常分裂中发挥重要作用。但是目前有关CENP-M与癌症的研究很少。因此，本实验旨在探讨CENP-M的表达水平与乳腺癌预后之间的关系。  方法  利用Oncomine 数据库、COSMIC数据库、bc-GenExMiner、Kaplan-Meier plotter、cBioPortal、GEPIA和Timer数据库系统，分析CENP-M 的表达和乳腺癌预后情况。  结果  与正常组织相比，CENP-M在乳腺癌组织（尤其在侵袭性导管乳腺癌、侵袭性筛状乳腺癌和黏液性乳腺癌）中表达上调；基因突变分析表明，CENP-M表达增加不是由基因序列或拷贝数的改变引起的；CENP-M的表达和乳腺癌不同分型以及Scarff-Bloom-Richarolsn(SBR)分级相关；CENP-M高表达的乳腺癌患者预后较差；乳腺癌中CENP-M的表达和CDC45的表达相关。  结论  CENP-M可以作为乳腺癌患者的预后标志物。

关键词: 着丝粒蛋白M, 乳腺癌, 预后, CDC45, Oncomine数据库, 分析

Abstract:

Objective  Centromere protein M(CENP-M) is an important member of constitutive centromere-associated network（CCAN）protein family. And it guarantees the correct formation and function of centromeres and kinetochores, and plays an important role in normal cell division. However, there are only a few studies on the relationship between CENP-M and cancers. Therefore, the aim of this study is to explore the relationship between CENP-M expression and prognosis of breast cancer.   Methods  CENP-M expression and prognosis in breast cancer were analyzed through datebases, including Oncomine, COSMIC, bc-GenExMiner, Kaplan-Meier plotter, cBioPortal, GEPIA and Timer.   Results  Compared with the normal tissue samples, the expression of CENP-M was up-regulated in various cancers, and the highest expression was found in breast cancer(especially in invasive ductal breast cancer，invasive cribriform breast adenocarcinoma and mucinous breast carcinom); According to analysis of genic mutation, the increase of CENP-M expression was not due to the change of the sequence or copy number of the gene; The expression of CENP-M was correlated with different types and Scarff-Blom-Richordson(SBR) stages of breast cancer; Breast cancer patients with high CENP-M expression had poor prognosis; The expression of CENP-M was correlated with the expression of CDC45 in breast cancer.   Conclusion  CENP-M can be a prognostic biomarker for breast cancer patients.

Key words: Centromere protein M, Breast cancer, Prognosis, CDC45, Oncomine datebase, Analysis

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