脑血管发育的分子机制

doi:10.16098/j.issn.0529-1356.2022.05.022

摘要/Abstract

摘要：

作为大脑中营养和氧气的输送管道，脑血管对大脑的发育及正常功能的发挥具有重要意义。脑血管系统的发育分为原始血管发生和血管生成两个过程。我们针对在上述过程中扮演重要角色的重要分子，如血管内皮生长因子（VEGF）、Neuropillin、Wnt、Notch、Hedgehog家族成员等在脑血管发生、形成和维持中的作用、调控机制和相互影响进行综述，以期为脑血管的基础研究和临床研究以及有关疾病的防治提供参考。

关键词: 脑血管生成, 血管再生, 血管内皮生长因子, Wnt信号通路, Notch信号通路

Abstract:

As the pipelines of nutrient and oxygen in the brain, cerebral vessels play an important role in the development and normal function of the brain. The development of the cerebrovascular system is divided into two processes, primitive vasculogenesis and angiogenesis. In this review, we summarize the roles, regulation mechanisms, as well as the interactions of the essential signaling molecules, such as the family members of vascular endothelial growth factor (VEGF), neuropillin, Wnt, Notch, Hedgehog, in the vessel development, aiming to provide a reference for the basic and clinical investigation and the prevention and treatment of vascular diseases.

Key words: Cerebral angiogenesis, Angiogenesis, Vascular endothelial growth factor, Wnt signaling pathway, Notch signaling pathway

中图分类号:

R321
R34

张思琦康晨曦张佩艳雒海霞李飞史娟李云庆. 脑血管发育的分子机制[J]. 解剖学报, 2022, 53(5): 680-686.

ZHANG Si-qi KANG Chen-xi ZHANG Pei-yan LUO Hai-xia LI Fei SHI Juan LI Yun-qing . Molecular mechanism underlying vascular development in the brain[J]. Acta Anatomica Sinica, 2022, 53(5): 680-686.

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