肝窦内皮细胞的窗孔调控与脂肪肝形成的研究进展

doi:10.16098/j.issn.0529-1356.2017.06.023

解剖学报 ›› 2017, Vol. 48 ›› Issue (6): 766-770.doi: 10.16098/j.issn.0529-1356.2017.06.023

• 综述 • 上一篇

肝窦内皮细胞的窗孔调控与脂肪肝形成的研究进展

王巧稚^1.2 樊婧¹ 张卫光^1*

1.北京大学基础医学院人体解剖学与组织学胚胎学系，北京 100191; 2.西南医科大学组织学与胚胎学教研室，四川泸州 646000

收稿日期:2017-06-29 修回日期:2017-09-01 出版日期:2017-12-06 发布日期:2017-12-06
通讯作者: 张卫光 E-mail:zhangwg@bjmu.edu.cn
基金资助:
分数阶微积分研究肝血窦内非定常流动对肝细胞脂肪变性的影响

Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis

WANG Qiao-zhi ^1.2 FAN Jing¹ZHANG Wei-guang^1*

1. Department of Anatomy and Histoembryology, School of Basic Medical Sciences, Peking University, Beijing 100191, China;2. Department of Histology and Embryology, Southwest Medical University, Sichuan Luzhou 646000, China

Received:2017-06-29 Revised:2017-09-01 Online:2017-12-06 Published:2017-12-06
Contact: ZHANG Wei-guang E-mail:zhangwg@bjmu.edu.cn

摘要/Abstract

摘要：

衬贴于肝血窦的肝窦内皮细胞具有无隔膜的窗孔，并汇聚成肝筛。窗孔相当于可选择超滤系统，有利于调控肝细胞与肝窦血液的物质交换，尤其是在脂质代谢方面，窗孔结构异常是脂质代谢紊乱的重要因素。本文就窗孔的超微结构、开窗机制和调控因素以及与脂肪肝相关联系的进展做一综述。

关键词: 脂肪肝, 肝窦内皮细胞, 窗孔, 脂代谢

Abstract:

Liver sinusoidal endothelial cells (LSECs) are gossamer-thin cells that line the hepatic sinusoid and they are perforated with pores called fenestrations clustered in sieve plates. There is growing evidence that fenestrations may work as a permselective ultrafiltration installation which is important for the hepatic to uptake substrates, particularly metabolism of lipoproteins. Abnormal fenestratel structure had been considered as a vital factor to liver lipid metabolism disorders. This review mainly focused on the relationship between ultrastructure of the fenestration, the fenestrated mechanism, the regulation factor of fenestration, and hepatic steatosis.

Key words: Hepatic steatosis, Liver sinusoidal endothelial cell, Fenestration, Lipid metabolism

王巧稚樊婧张卫光. 肝窦内皮细胞的窗孔调控与脂肪肝形成的研究进展[J]. 解剖学报, 2017, 48(6): 766-770.

WANG Qiao-zhi FAN Jing ZHANG Wei-guang. Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis[J]. Acta Anatomica Sinica, 2017, 48(6): 766-770.

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肝窦内皮细胞的窗孔调控与脂肪肝形成的研究进展

Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis

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