南京2504例0～3岁婴幼儿的骨密度

doi:10.16098/j.issn.0529-1356.2019.06,021

摘要/Abstract

摘要：

目的探讨年龄、性别、孕期母亲补钙、佝偻病早期症状与骨密度Z值的关系，为更好地预防儿童佝偻病和低骨密度工作提供依据和建议。方法对南京市秦淮区妇幼保健所儿保门诊的2504例0～3岁婴幼儿，用定量超声骨密度仪对其骨密度进行检测，分析骨密度不足检出率与年龄、性别、孕期补钙情况、佝偻病早期症状之间的关系。结果 0～3岁女童骨密度Z值总体低于男童（P＜0.001）。在0～3月，3～6月，6月～1岁3个年龄段中，女童骨密度不足的发生率均明显高于男童（P＜0.001）。1～3岁年龄段中，男女童骨密度不足检出率差异无统计学意义（P＞0.05）。3～6月年龄段的婴儿骨密度不足检出率最高，达83.5%，其中女童骨密度不足检出率占该年龄总案例的51.0%。佝偻病早期症状与骨密度不足检出率差异有统计学意义（P＜0.001）。母亲孕期补钙与骨密度不足检出率差异无统计学意义（P＞0.05）。结论要定期监测婴幼儿骨密度，关注1岁以内小儿的骨密度，尤其关注女童。

关键词: 骨密度, 性别, 年龄, 超声骨密度检测, 婴幼儿

Abstract:

Objective To investigate the relationship between age, gender, calcium supplementation during pregnancy, early symptoms of rickets and Z value of bone mineral density, and to provide evidence and recommendations for better prevention of rickets and low bone density in children. Methods Two thousand five hundred and four cases of infants aged 0-3 years old in the Qinhuai District Maternal and Child Health Hospital of Nanjing were tested with quantitative ultrasound bone density. The detection rate of bone mineral density was analyzed and age, sex, calcium supplementation during pregnancy and early stage of rickets. The relationship between symptoms. Results The bone mineral density Z value of girls aged 0-3 was lower than that of boys (P<0.001). In the 0-3 months, 3-6 mohth, 6 months-1 year groups, the incidence of under-bone density was significantly higher in girls than in boys (P<0.001). There was no significant difference in the detection rate of bone mineral density between boys and girls in the 1-3 years group (P>0.05). In the 3-6 months, the detection rate of infant bone mineral density was the highest, reaching 83.5%. The detection rate of girls with insufficient bone mineral density accounted for 51.0% of the total case of this age. There was a statistically significant difference in the detection rate of early symptoms and insufficient bone mineral density (P<0.001). There was no significant difference in the detection rate of calcium supplementation and bone mineral density during pregnancy (P>0.05). Conclusion It is necessary to regularly monitor the bone mineral density of infants and children, and pay attention to the bone mineral density of children within 1 year old, especially to girls.

Key words: Bone density, Gender, Age, Utrasound bone mineral density test, Infant

林微微. 南京2504例0～3岁婴幼儿的骨密度[J]. 解剖学报, 2019, 50(6): 823-826.

LIN Wei-wei. Bone mineral density of 2504 infants aged 0-3 years in Nanjing[J]. Acta Anatomica Sinica, 2019, 50(6): 823-826.

参考文献

［1］ Steelman J, Zeitler P. Osteoporosis in pediatrics ［J］.Pediatr Rev, 2001, 22(2):56-65.

［2］ Li Y. Application of ultrasound bone mineral density in Children’s Health Care ［J］.Chinese Journal of Birth Health and Heredity,2016，24（1）：125-126.（in Chinese）

黎燕.超声骨密度在儿童保健科的应用分析［J］. 中国优生与遗传杂志,2016，24（1）：125-126.

［3］ Liang W. Diagnostic value of ultrasonic bone density determination for early caries in infants［J］. Chinese Journal of Clinical Research,2016，29（1）：103-105.（in Chinese

梁伟.超声骨密度测定对婴幼儿早期佝偻病的诊断价值［J］.中国临床研究,2016，29（1）：103-105.

［4］ Chen RH, Zhao ZhY, Liu XY. Child Health Care ［M］. 4th ed. Jiangsu Phoenix Science and Technology Publishing House, 2017：61.（in Chinese）

陈荣华，赵正言，刘湘云.儿童保健学［M］. 第4版.江苏凤凰科学技术出版社，2017：61.

［5］ Zhang Y, Shen MQ. Analysis of bone mineral density of 2083 infants aged 0-3 years old［J］. Chinese Journal of Child Health Care，2016,24（1）： 99-100. (in Chinese)

张莺，沈明强.婴幼儿超声骨密度2083例结果分析［J］.中国儿童保健杂志，2016,24（1）：99-100.

［6］ Yin GZh, Wang Y, Dong W. Analysis of ultrasound bone mineral density in 4551 healthy children aged 0-3 in Hefei city［J］. Chinese Journal of Women and Children Health, 2015,6（3）：56-57.(in Chinese)

殷刚柱，王燕，董皖.合肥市4551名0-3岁健康儿童超声骨密度检测结果分析［J］.中国妇幼卫生杂志，2015,6（3）：56-57.

［7］ Zhang PP, Yang LF, Li XF, et al. Ultrasonic bone mineral density measurement and analysis of 2450 children in Guangzhou area［Ｊ］. China Tropical Medicine, 2015,15（9）：1098-1101.(in Chinese)

张萍萍，杨丽芬，李晓峰，等.广州地区2450例儿童超声骨密度测定与分析［J］.中国热带医学，2015,15（9）：1098-1101.

［8］ Zhang HL, Yang LF, He HR, et al. Analysis of bone mineral density measured by ultrasonicin 7207 children aged 0-3 years old in Xi’an city［J］.Chinese Journal of Child Health Care，2017,25（1）：81-84.(in Chinese)

张华丽，杨丽芳，何红茹，等.西安市0-3岁婴幼儿超声骨密度7207例分析［J］. 中国儿童保健杂志,2017,25（1）：81-84.

［9］ Kalkwarf HJ, Zemel BS, Yolton K, et al. Bone mineral content and density of the lumbar spine of infants and toddlers:influence of age, sex, race, growth, and human milk feeding［J］. J Bone Miner Res, 2013,28(1):206-212.

［10］ Xu H, Zhao Z, Wang H, et al. Bone mineral density of the spine in 11 898 Chinese infants and young children: a crosssectional study［J］. PLoS One, 2013, 8(12): e82098

［11］ Huang GF, Li HF, Liu YX, Influencing factors of bone mineral density in Zhanghua children［J］. Maternal and Child Health Care of China, 2014,29（23）：3762-3764.(in Chinese)

黄桂芳，李海飞，刘一心.小儿骨密度相关影响因素分析［J］.中国妇幼保健，2014,29（23）：3762-3764.

［12］ Owell K, Keen C, Uriu-Adams J. Vitamin D and reproduction:from gametes to childhood［J］.Healthcare,2015,3(4):1097-1120.

［13］ Ilich JZ，Hsieh LC，Tzagournis MA，et al. A comparison of singlephoton and dual X-ray absorptiometry of the forearm in children andadults［J］. Bone， 1994，15(2): 187-19

［14］ Zhang H, Bai Y, Zhao M, et al. Female skeletal health management strategy under the new development concept［J］. Chinese Remedies and Clinics，2017， 17（6）:843-845. (in Chinese)

张红，白云，赵敏，等.新发展理念下女性骨骼健康管理策略［J］.中国药物与临床2017， 17（6）:843-845.

[1]	洪晓敏李三强崔钦奕郑润月杨孟利罗仁利李前辉 . 酒精性肝纤维化核因子κB信号通路与性别的差异 [J]. 解剖学报, 2024, 55(1): 55-61.
[2]	成芷菡冉智宇凌亮优何嘉宁. 华北地区明清古代人群肱骨远端形态的性别差异[J]. 解剖学报, 2023, 54(3): 328-334.
[3]	李甲一席焕久温有锋桂超张晓明张海龙 . 辽宁省汉族成人少肌症、少肌性肥胖与骨质疏松症的相关性[J]. 解剖学报, 2023, 54(2): 238-243.
[4]	王子慧郭建林臧夏炎薛奇杰林凯琳张春博韩璐林俊堂徐存拴 . 大鼠肝再生的肝细胞干性变化中性别决定区转录因子2 mRNA和其他非编码RNA的表达变化与作用[J]. 解剖学报, 2023, 54(2): 202-207.
[5]	黄婷李欣兰蕙温有锋. 哈萨克族舌运动类型及其相互关系[J]. 解剖学报, 2022, 53(6): 802-807.
[6]	易灿李咏兰于会新 . 中国壮侗语族族群Heath-Carter法体型特征[J]. 解剖学报, 2022, 53(2): 254-260.
[7]	张帅军. 中等强度运动对去卵巢大鼠骨质疏松及骨形态发生蛋白2信号通路的影响[J]. 解剖学报, 2020, 51(6): 934-939.
[8]	黄彬彬王泽峰陈润黄晓婷周鹤唐成张文海黄丽仟刘鹏. 广西成人身体脂肪参数随年龄变化趋势[J]. 解剖学报, 2020, 51(2): 300-305.
[9]	周亚威周贝顾万发. 汪沟遗址仰韶文化居民的肢骨特征[J]. 解剖学报, 2020, 51(1): 114-123.
[10]	姚婕温有锋陈影宋佳刘莹莹. 拉萨藏族成人握力调查[J]. 解剖学报, 2020, 51(1): 124-127.
[11]	梁玉何玉秀郑连斌张静刘少强康琛哲. 青海撒拉族乡村成人围度特征及其增龄性变化[J]. 解剖学报, 2019, 50(3): 374-382.
[12]	王志刚刘伟. 应用转录组和外显子组测序分析不同年龄组的胶质母细胞瘤中基因表达与突变的差异[J]. 解剖学报, 2019, 50(1): 8-12.
[13]	陈兴才李炎玉洪荣龚健古周丽宁龚继春徐林邓琼英. 广西少数民族成年女性骨密度的差异及年龄变化特点[J]. 解剖学报, 2018, 49(5): 683-687.
[14]	李海军樊晓霞方璐瑜戴成萍. 下颌骨若干测量性状的时代间比较[J]. 解剖学报, 2018, 49(4): 535-539.
[15]	钟铧张海龙席焕久李幼琼昂旺格桑于泽明. 藏族和汉族青年人群掌指形态特征分析[J]. 解剖学报, 2018, 49(1): 113-117.