微流控技术在辅助生殖领域应用的研究进展

doi:0.16098/j.issn.0529-1356.2021.02.026

解剖学报 ›› 2021, Vol. 52 ›› Issue (2): 323-328.doi: 0.16098/j.issn.0529-1356.2021.02.026

• 综述 • 上一篇

微流控技术在辅助生殖领域应用的研究进展

王中立^1,2王琪³ 邓娟⁴ 雷兰杰^4,5 杨磊^2,5*

1.九江学院护理学院，江西九江 332000; 2.江西省系统生物医学重点实验室, 江西九江 332000; 3.西北妇女儿童医院生殖中心，西安 710003; 4.九江学院临床医学院，江西九江 332000; 5.东南大学生物电子学国家重点实验室，南京 210018

收稿日期:2019-11-01 修回日期:2019-12-16 出版日期:2021-04-06 发布日期:2021-04-06
通讯作者: 杨磊 E-mail:yangleigeili@163.com
基金资助:
基于‘未病’理论早期应激致PTSD易感及人参的预防效应机制研究;雌激素靶向作用于GPER下调CNP表达的机制研究;雌激素双向调控小鼠颗粒细胞CNP表达的机制研究;基于调节海马星形胶质细胞EAATs功能的人参抗应激作用及机制研究;miRNA431靶向作用于IRS2调控人卵巢颗粒细胞功能的机制研究;铬中毒在小鼠子宫内膜退膜化过程中的作用和机制;ICA在糖尿病神经病理性疼痛中的作用及机制研究

Advances in the application of microfluidic technology in assisted reproduction

WANG Zhong-li^1,2 WANG Qi³ DENG Juan⁴ LEI Lan-jie^4,5 YANG Lei^2,5*

1. School of Nursing, Jiujiang University, Jiangxi Jiujiang 332000, China.2. Key Laboratory of System Bio-Medicine of Jiangxi Province, Jiujiang University, Jiangxi Jiujiang 332000, China;3. Reproductive center, Northwest Women and Children’s Hospital, Xi’an 710003, China; 4. Affiliated Hospital of Jiujiang University, Jiujiang University, Jiangxi Jiujiang 332000, China; 5. State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210018, China

Received:2019-11-01 Revised:2019-12-16 Online:2021-04-06 Published:2021-04-06
Contact: YANG Lei E-mail:yangleigeili@163.com

摘要/Abstract

摘要：

辅助生殖技术（ART）领域进展迅速，由于临床实践中操作步骤繁琐，如分选精子，卵母细胞的选择，体外受精，胚胎培养，胚胎的监测等，所以在效率和临床决策方面仍有进一步改进的需求。微流控技术既是技术手段也是一门科学，它是在亚微升水平研究流体的行为特征。其检测系统管道及检测终端具有极大灵活性，可适用于不同的检测目的，其检测精度高的同时节省样本量，具有高度集成性特征，与辅助生殖实践中的检测需求相匹配。应用微流控技术可以评估精子，卵母细胞和植入前胚胎结构功能和环境等基本生物学信息，并据此给予准确有效的应对方案和临床决策。基于上述内容，本文中我们就微流控技术在辅助生殖上的应用作一综述，以期推进微流控技术在生殖领域的应用和完善。

关键词: 辅助生殖技术, 卵母细胞, 胚胎, 分选, 微流控

Abstract:

The field of assisted reproductive technology (ART) has made rapid progress. Due to the complicated procedures in clinical practice, such as sperm sorting, oocyte selection, fertilization, embryo culture and embryo monitoring, there is still a need for further improvement in efficiency and clinical decision-making. Microfluidic technology is not only a technical means but also a science, which studies the behavior characteristics of fluid at the sub-microlevel. The pipeline and detection terminal of the detection system have great flexibility and can be applied to different detection purpose. It has high detection accuracy and saves the size of samples. It has the characteristics of high integration and matches the detection needs in the practice of assisted reproduction. The application of microfluidic technology can evaluate the basic biological information such as the structure, function and environment of spermatozoa, oocytes and preimplantation embryos, and make accurate and effective coping lans and clinical decisions. This paper reviews the application of microfluidic technology in assisted reproduction, in order to promote the application and improvement of microfluidic technology in the field of reproduction.

Key words: Assisted reproductive technology, Oocyte, Embryo, Sorting, Microfluidics

中图分类号:

O658

王中立王琪邓娟雷兰杰杨磊. 微流控技术在辅助生殖领域应用的研究进展[J]. 解剖学报, 2021, 52(2): 323-328.

WANG Zhong-li WANG Qi DENG Juan LEI Lan-jie YANG Lei. Advances in the application of microfluidic technology in assisted reproduction[J]. Acta Anatomica Sinica, 2021, 52(2): 323-328.

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微流控技术在辅助生殖领域应用的研究进展

Advances in the application of microfluidic technology in assisted reproduction

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