衰老过程中沿血管周围间隙弥散张量成像分析指数的改变

doi:10.16098/j.issn.0529-1356.2024.04.017

解剖学报 ›› 2024, Vol. 55 ›› Issue (4): 501-507.doi: 10.16098/j.issn.0529-1356.2024.04.017

衰老过程中沿血管周围间隙弥散张量成像分析指数的改变

黄辰烨¹李祥君¹谢道俊^1,2*

1.安徽中医药大学第一临床医学院，合肥 230031; 2.安徽中医药大学第一附属医院脑病中心，合肥 230031

收稿日期:2024-01-17 修回日期:2024-03-14 出版日期:2024-08-06 发布日期:2024-08-06
通讯作者: 谢道俊 E-mail:daojunxie81@163.com
基金资助:
化痰祛瘀方调控PI3K-AKT-mTOR信号通路诱导神经元自噬改善WD认知障碍的机制研究

Changes in diffusion tensor image analysis along the perivascular space index during aging

HUANG Chen-ye¹ LI Xiang-jun¹ XIE Dao-jun^1,2*

1.The First Clinical Medical College, Anhui University of Traditional Chinese Medicine, Hefei 230031，China; 2.Brain Disease Center, the First Affiliated Hospital, Anhui University of Traditional Chinese Medicine, Hefei 230031, China

Received:2024-01-17 Revised:2024-03-14 Online:2024-08-06 Published:2024-08-06
Contact: XIE Dao-jun E-mail:daojunxie81@163.com

摘要/Abstract

摘要：

目的基于沿血管周围间隙弥散张量成像分析（DTI-ALPS）,计算DTI-ALPS指数，评估脑类淋巴系统的功能，观察DTI-ALPS指数在衰老过程中的改变，并寻找DTI-ALPS指数与某些可体现思维灵活性的执行功能的相关性。方法使用FSL工具箱提取内森·克莱恩研究所罗克兰数据集内成年志愿者大脑优势半球侧DTI-ALPS指数，分析DTI-ALPS指数分别与年龄和设计流畅性实际准确度之间的相关性，DTI-ALPS指数在不同年龄段上的差异，以及DTI-ALPS指数在年龄和设计流畅性实际准确度之间的中介效应。结果 DTI-ALPS指数与年龄成负相关（r=-0.288，P<0.001），但在60~69岁年龄段分组中存在回升的局部高峰（P<0.01）；DTI-ALPS指数与设计流畅性实际准确度成正相关（r=0.258，P=0.001）；DTI-ALPS指数在年龄和设计流畅性实际准确度之间的中介效应有统计学意义（P<0.05），中介效应占总效应的比例为22.1%。结论衰老过程中DTI-ALPS指数呈总体降低趋势，但是在60~69岁年龄段分组中存在局部回升的高峰，同时，DTI-ALPS指数可能与某些可体现思维灵活性的执行功能相关。

关键词:

衰老, 脑类淋巴系统, 沿血管周围间隙弥散张量成像分析, 人

Abstract:

Objective To calculate the diffusion tensor image analysis along the perivascular space(DTI-ALPS) index, evaluate the function of the glymphatic system, observe the changes in the DTI-ALPS index during the aging process, and find the relationship between the DTI-ALPS index and correlates of certain executive functions that reflect mental flexibility, based on DTI-ALPS. Methods The FSL toolbox was used to extract the DTI-ALPS index of the dominant hemisphere of the brain of adult subjects in the NKI Rockland Sample data set, and the correlations between the DTI-ALPS index and age and design fluency practical accuracy were analyzed, respectively. Differences in DTI-ALPS index among different age groups and the mediating effect of DTI-ALPS index between age and design fluency practical accuracy were analyzed. Results The DTI-ALPS index was negatively correlated with age (r=-0.288, P<0.001), but there was a local peak of recovery in the 60-69 age group (P<0.01).The DTI-ALPS index was positively correlated with the design fluency practical accuracy (r=0.258, P=0.001).The mediating effect of DTI-ALPS index between age and design fluency practical accuracy was statistically significant (P<0.05), and the mediating effect accounted for 22.1% of the total effect. Conclusion The DTI-ALPS index showed an overall downward trend during the aging process, but there is a local peak of recovery in the 60-69 age group. At the same time, the DTI-ALPS index might be related to certain executive functions that could reflect thinking flexibility.

Key words:

Aging, Glymphatic system, Diffusion tensor image analysis along the perivascular space, Human

中图分类号:

R338.2

黄辰烨李祥君谢道俊. 衰老过程中沿血管周围间隙弥散张量成像分析指数的改变[J]. 解剖学报, 2024, 55(4): 501-507.

HUANG Chen-ye LI Xiang-jun XIE Dao-jun. Changes in diffusion tensor image analysis along the perivascular space index during aging[J]. Acta Anatomica Sinica, 2024, 55(4): 501-507.

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衰老过程中沿血管周围间隙弥散张量成像分析指数的改变

Changes in diffusion tensor image analysis along the perivascular space index during aging

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