Association between the polymorphism of aldosterone synthase gene promoter-344T/C and preeclampsia in Qinghai Province

doi:10.16098/j.issn.0529-1356.2021.02.023

Abstract

Abstract:

Objective To investigate the relationship between preeclampsia (PE) and polymorphism of aldosterone synthase gene (CYP11B2) promoter region-344T/C in Qinghai Province. Methods A total of 120 PE subjects and 155 normal pregnancy subjects were studied. The genotype of CYP11B2 was analyzed by polymerase chain reaction fragment length polymorphism (PCR-RFLP)．The mutation was confirmed by sequencing. Results The frequencies of CYP11B2 TT, CT and CC genotype in the PE group were 43.0%, 45.6%, and 11.4%, and in the control group were 51.0%, 45.1%, and 3.9%, respectively. There was difference in frequency distribution of CYP11B2 genotype between the PE and control groups．The frequency of C allele in the PE group was higher than the control group（χ2=4.354，P<0.05, OR=0.691, 95% CI=0.49-0.98）. Conclusion The CYP11B2-344T/C polymorphism is related to preeclampsia in Qinghai Province, and the C allele may be a susceptibility gene of preeclampsia.

Key words: Qinghai, Aldosterone synthase, Preeclampsia, Gene polymorphism, Restriction fragment length polymorphism polymerase chain reaction, Pregnant woman

CLC Number:

LI Wen-jia WANG Ru DUAN Qian LI Chang-xing LI Hong-rong LI Jian-hua. Association between the polymorphism of aldosterone synthase gene promoter-344T/C and preeclampsia in Qinghai Province[J]. Acta Anatomica Sinica, 2021, 52(2): 306-310.

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