胰腺癌性痛发生、发展的神经机制研究进展

doi:10.16098/j.issn.0529-1356.2021.04.026

摘要/Abstract

摘要：

胰腺癌性痛属于癌症引起的内脏痛，患者常常具有左上腹疼痛的特点，且在背部呈带状放射，严重影响患者的预后和生活质量。胰腺属于腹膜后位器官，周围有大量的神经丛包绕，受交感神经和副交感神经的共同支配。胰腺癌性痛机制复杂，如胰腺癌肿瘤细胞对周围神经的侵袭、肥大细胞脱颗粒物使受体激活、新生毛细血管增生、神经胶质细胞参与以及多种分子水平机制等。掌握胰腺的神经解剖学特征，探索胰腺癌性痛的机制对于临床治疗胰腺癌患者疼痛以及提高其预后和生活质量非常必要。我们就胰腺癌的神经病理性痛机制做一综述，以期为临床治疗胰腺癌性痛提供新的靶点和策略。

关键词: 胰腺癌性痛, 内脏痛, 神经系统, 机制

Abstract:

Pancreatic cancer pain is a kind of visceral pain caused by cancer. Patients often have the characteristics of left upper abdominal pain and band radiation on the back, which seriously affects the prognosis and quality of life of the patients. Pancreas is a retroperitoneal organ and distributed with sympathetic nerve and parasympathetic nerve. The mechanism of pancreatic cancer pain is complex, such as the invasion of peripheral nerve by tumor cells, the activation of receptor by mastocyte departiculate action, the proliferation of new capillaries, the involvement of glial cells, and the related molecular mechanisms. It is necessary to understand the neuroanatomical characteristics of pancreas and explore the mechanism of pancreatic cancer pain in order to relieve the pain and improve the prognosis and quality of life of patients with pancreatic cancer. In this paper, the neuropathic pain mechanism of pancreatic cancer is reviewed in order to provide a new target and strategy for clinical treatment.

Key words: Pancreatic cancer pain, Visceral pain, Nervous system, Mechanism

中图分类号:

Q189

邱欣彤李仪曹鹏张明明. 胰腺癌性痛发生、发展的神经机制研究进展[J]. 解剖学报, 2021, 52(4): 670-674.

QIU Xin-tong LI Yi CAO Peng ZHANG Ming-ming. Research progress on neural mechanism of pancreatic cancer pain[J]. Acta Anatomica Sinica, 2021, 52(4): 670-674.

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